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Clinical trial data from the SURMOUNT series shows these incidence rates: Nausea: approximately 20 percent of patients Diarrhea: approximately 16 percent of patients Vomiting: approximately 9 percent of patients Constipation: varies by dose level Decreased appetite: expected therapeutic effect Abdominal pain: less common but reported Most gastrointestinal side effects are mild to moderate and occur during the first few weeks of treatment or after dose increases

Where Phase I or Phase II human trials exist, they are noted in the compound page summary

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[12] [13] Avoid aggressive hair treatments: During periods of shedding, minimising heat styling, chemical treatments, and tight hairstyles can reduce additional mechanical stress on fragile hair